In recent years, there has been growing interest in healthcare systems research worldwide to improve care quality, patient safety, and operation efficiency. In this talk, we will first discuss the evolution of Industry 4.0, then introduce the idea of Healthcare 4.0, i.e., the smart and interconnected healthcare systems. We will present lessons we learned and results we obtained during the journey of manufacturing systems research to healthcare delivery system study. We will introduce the problems and issues, and then address the difficulties and opportunities in healthcare delivery systems. In addition, we will provide a brief description of recent studies in healthcare delivery systems carried out at the Production and Service Systems Lab at the University of Wisconsin-Madison. Finally, we will discuss the challenges and future directions in smart and interconnected healthcare systems research. Speaker(s): JINGSHAN, Virtual: https://events.vtools.ieee.org/m/320798